Paper highlights

"Stepwise Hydration Reveals Conformational Switching in Chiral Prolinol" Donatella Loru, Elena R. Alonso, Aran Insausti, Cristóbal Pérez, Luca...

"Insights into the Catalytic Activity of a Metagenome-Derived Urethanase" Katarzyna Świderek, Kemel Arafet, Victor de Sousa Batista, Daniel...

"Structural basis for amyloid fibril assembly by the master cell-signaling regulator receptor-interacting protein kinase 1" Paula Polonio, Jorge...

"Elucidating the structure and assembly mechanism of actinoporin pores in complex membrane environments" Rocío Arranz, César Santiago, Simonas...

Mechanically knocking out titin reveals protein tension loss as atrigger of muscle disease. Silva-Rojas R, Vicente N, Gavilán-Herrera M,...

"Enzyme Enhancement Through Computational Stability Design Targeting NMR-DeterminedCatalytic Hotspots. "   Gutierrez-Rus LI, Vos E, Pantoja-Uceda D,...

Resouring susceptibility to β-lactam antibiotics in methicillin-resistant Staphylococcus aureus.  Nguyen VT, Birhanu BT, Miguel-Ruano V, Kim C,...

Real-space heterogeneous reconstruction, refinement, and disentanglement of CryoEM conformational states with HetSIREN. Herreros D, Mata CP,...

"Exploring the druggability of the UEV domain of human TSG101 in search for broad-spectrumantivirals. " Montero F, Parra-López M, Rodríguez-Martínez...

Photoswitchable Diazocine Derivative for Adenosine A3 Receptor Activation in Psoriasis   López-Cano M, Scortichini M, Tosh DK, Salmaso V, Ko T,...

"A lever hypothesis for Synaptotagmin-1 action in neurotransmitter release." JJaczynska K, Esser V, Xu J, Sari L, Lin MM, Rosenmund C, Rizo J.  Proc...

Mis-splicing of a neuronal microexon promotes CPEB4 aggregation in ASD. Garcia-Cabau C, Bartomeu A, Tesei G, Cheung KC, Pose-Utrilla J, Picó...

Stacking correlation length in single-stranded DNA. Viader-Godoy X, Manosas M, Ritort F. Nucleic Acids Res. 2024 Nov 27;52(21):13243-13254....

Tensing Flipper: Photosensitized Manipulation of Membrane Tension, Lipid Phase Separation, and Raft Protein Sorting in Biological Membranes Torra J,...

Membrane fission via transmembrane contact Spencer RKW, Santos-Pérez I, Rodríguez-Renovales I, Martinez Galvez JM, Shnyrova AV & Müller M Nat...

Single-Molecule Analysis of Genome Uncoating from Individual Human Rhinovirus Particles, and Modulation by Antiviral Drugs Valbuena A, Strobl K,...

Transition of human γ-tubulin ring complex into a closed conformation during microtubule nucleation Brito C, Serna M, Guerra P, Llorca O &...

Variance sum rule for entropy production Di Terlizzi I, Gironella M, Herraez-Aguilar D, Betz T, Monroy F, Baiesi M & Ritort F Science 383(6686):...

Charged Biological Membranes Repel Large Neutral Molecules by Surface Dielectrophoresis and Counterion Pressure M Aguilella-Arzo, D P Hoogerheide, M...

Molecular Dynamic Simulations of Aqueous Micellar Organometallic Catalysis: Methane Functionalization as a Case Study A Matamoros-Recio, E...

Flexible structural arrangement and DNA-binding properties of protein p6 from Bacillus subtillis phage φ29 M Alcorlo, J R Luque-Ortega, F Gago, A...

Three-Photon Infrared Stimulation of Endogenous Neuroreceptors in Vivo R Sortino, M Cunquero, G Castro-Olvera, R Gelabert, M Moreno, F Riefolo, C...

Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α J Pous, B Baginski, P Martin-Malpartida, L...

Rational optimization of a transcription factor activation domain inhibitor S Basu, P Martínez-Cristóbal, M Frigolé-Vivas, M Pesarrodona, M Lewis, E...

Molecular Sensing and Manipulation of Protein Oligomerization in Membrane Nanotubes with Bolaamphiphilic Foldamers K Aftahy, P Arrasate, P V...

Three-Dimensional Remodeling of SARS-CoV2-Infected Cells Revealed by Cryogenic Soft X-ray Tomography V Castro, A Joaquina Pérez-Berna, G Calvo, E...

Structural and functional insights into the delivery of a bacterial Rhs pore-forming toxin to the membrane A González-Magaña, I Tascón, J...

The laminin–keratin link shields the nucleus from mechanical deformation and signalling Z Kechagia, P Sáez, M Gómez-González, B Canales, S...

A MEC-2/stomatin condensate liquid-to-solid phase transition controls neuronal mechanotransduction during touch sensing N Sanfeliu-Cerdán, F...

Single─Not Double─3D-Aromaticity in an Oxidized Closo Icosahedral Dodecaiodo-Dodecaborate Cluster J Poater, S Escayola, A Poater, F Teixidor, H...

The Protein Matrix of Plastocyanin Supports Long-Distance Charge Transport with Photosystem I and the Copper Ion Regulates Its Spatial Span and...

Sub-micro- and nano-sized polyethylene terephthalate deconstruction with engineered protein nanopores Robles-Martín A, Amigot-Sánchez R,...

The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70 L Velasco-Carneros, J Cuéllar,...

A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale X Quiroga, N Walani. A Disanza, A Chavero, A Mittens, F...

Mitochondrial integrated stress response controls lung epithelial cell fate S H Han, M Lee, Y Shin, R Giovanni, R P Chakrabarty, M M Herrerias, L A...

Amyloid Fibrils Formed by Short Prion-Inspired Peptides Are Metalloenzymes S Navarro, M Díaz-Caballero, F Peccati, L Roldán-Martín, M Sodupe & S...

A multi-enzyme machine polymerizes the Haemophilus influenzae type b capsule J O Cifuente, J Schulze, A Bethe, V Di Domenico, C Litschko, I Budde, L...

Cytochrome c lysine acetylation regulates cellular respiration and cell death in ischemic skeletal muscle P T Morse, G Pérez-Mejías, J Wan, A A...

Structural analysis of the Candida albicans mitochondrial DNA maintenance factor Gcf1p reveals a dynamic DNA-bridging mechanism A Tarrés-Solé, F...

Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway L González, L Díaz, J Pous, B Baginski, A...

Architecture of the ESCPE-1 membrane coat C Lopez-Robles, S Scaramuzza, E N Astorga-Simon, M Ishida, C D Williamson, S Baños-Mateos, D Gil-Carton, M...

Expanded Conformations of Monomeric Tau Initiate Its Amyloidogenesis MdC Fernández-Ramírez, K K-S Ng, M Menéndez, D V Laurents, R Hervás, & M...

Hybrid Plasmonic Nanostructures for Enhanced Single-Molecule Detection Sensitivity E K Herkert, D R Bermeo Alvaro, M Recchia, W Langbein, P Borri,...

LC3/GABARAP binding to fluid membranes is potentiated by ceramide YR Varela & A Alonso  Autophagy, 19(4): 1371-1373, (2023) doi:...

Correlated motions in DNA: beyond base-pair step models of DNA flexibility  K López-Güell, F Battistini, & M Orozco Nucleic Acids Research,...

Transgenic NADH dehydrogenase restores oxygen regulation of breathing in mitochondrial complex I-deficient mice B Jiménez-Gómez, P Ortega-Sáenz, L...

Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration PQ Nguyen, S Huecas, A Asif-Laidin, A...

Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases B Trastoy, JJ Du, JO Cifuente, L...

Mechanism of strand displacement DNA synthesis by the coordinated activities of human mitochondrial DNA polymerase and SSB I Plaza-G A, K M...

pH-Dependent Capping Interactions Induce Large-Scale Structural Transitions in i-Motifs I Serrano-Chacón, B Mir, L Cupellini, F Colizzi, M Orozco, N...

Facile Construction of New Hybrid Conjugation via Boron Cage Extension F Sun, S Tan, H-J Cao, C Lu, D Tu, J Poater, M Solà & H Yan J. Am. Chem....

Estimating conformational landscapes from Cryo-EM particles by 3D Zernike polynomials D Herreros, R R Lederman, J M Krieger, A Jiménez-Moreno, M...

Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3 J Garcia-Pardo, A Bartolomé-Nafría, A...

Metamorphism in TDP-43 prion-like domain determines chaperone recognition J Carrasco, R Antón, A Valbuena, D Pantoja-Uceda, M Mukhi, R Hervás, D V...

Molecular architecture and oligomerization of Candida glabrata Cdc13 underpin its telomeric DNA-binding and unfolding activity J Coloma, N...

Geometric deep learning reveals the spatiotemporal features of microscopic motion J Pineda, B Midtvedt, H Bachimanchi, S Noé, D Midtvedt, G Volpe...

LC3 subfamily in cardiolipin-mediated mitophagy: a comparison of the LC3A, LC3B and LC3C homologs M N Iriondo, A Etxaniz, Y R Varela, U Ballesteros,...

APLF and long non-coding RNA NIHCOLE promote stable DNA synapsis in non-homologous end joining S De Bragança, C Aicart-Ramos, R Arribas-Bosacoma, A...

Proton Transfers to DNA in Native Electrospray Ionization Mass Spectrometry: A Quantum Mechanics/Molecular Mechanics Study M Paulikat, J Aranda, E...

Chemical modulation of microtubule structure through the laulimalide/peloruside site J Estévez-Gallego, B Álvarez-Bernad, B Pera, C Wullschleger, O...

Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1 R Pluta, E Aragón, N A Prescott, L Ruiz, R A Mees, B...

Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus A Rivera-Calzada, R Arribas-Bosacoma, A Ruiz-Ramos, P...

Active boundary layers in confined active nematics J Hardoüin, C Doré, J Laurent, T Lopez-Leon, J Ignés-Mullol & F Sagués Nature Communications...

A glutamine-based single α-helix scaffold to target globular proteins A Escobedo, J Piccirillo, J  Aranda, T  Diercks, B  Mateos, C Garcia-Cabau, M...

Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid–liquid phase...

TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine D Alarcón-Alarcón, D Cabañero,...

CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase J P López-Alonso, M Lázaro, D Gil-Cartón, P H Choi, A Dodu, L Tong...

Mechanical strain stimulates COPII-dependent secretory trafficking via Rac1 Phuyal S, Djaerff E, Le Roux AL, Baker MJ, Fankhauser D, Mahdizadeh...

Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau Gracia P, Polanco D, Tarancón-Díez...

Stochastic particle unbinding modulates growth dynamics and size of transcription factor condensates in living cells Muñoz-Gil G, Romero-Aristizabal...

A quantitative biophysical principle to explain the 3D cellular connectivity in curved epithelia Gómez-Gálvez P, Vicente-Munuera P, Anbari S, Tagua...

The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation Ginex T,...

Mechanical force application to the nucleus regulates nucleocytoplasmic transport I Andreu, I Granero-Moya, N R Chahare, K Clein, M Molina-Jordán, A...