Architecture of DNAJA2 oligomers. Representative field of a CryoEM image of DNAJA2wt, a cochaperone of Hsp70, with a scale bar corresponding to 100 nm (left panel). The right panel displays side and top views of the atomic model of DNAJA2 fitted into the 3D reconstruction of the protein oligomer. The protein dimers align to form longitudinal filaments that interact laterally, resulting in the helical configuration. Each filament is depicted in distinct color.

The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70

L Velasco-Carneros, J Cuéllar, L Dublang, C Santiago, J-D Maréchal, J Martín-Benito, M Maestro, J Á Fernández-Higuero, N Orozco, F Moro, J M Valpuesta & A Muga

Nat Commun 14: 5436 (2023)

doi: 10.1038/s41467-023-41150-8