Paper highlights

#paperhighlights Dec2022 #3

#paperhighlights Dec2022 #3

APLF and long non-coding RNA NIHCOLE promote stable DNA synapsis in non-homologous end joining S De Bragança, C Aicart-Ramos, R Arribas-Bosacoma, A...

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#paperhighlights Dec2022 #2

#paperhighlights Dec2022 #2

Proton Transfers to DNA in Native Electrospray Ionization Mass Spectrometry: A Quantum Mechanics/Molecular Mechanics Study M Paulikat, J Aranda, E...

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#paperhighlights Dec2022 #1

#paperhighlights Dec2022 #1

Chemical modulation of microtubule structure through the laulimalide/peloruside site J Estévez-Gallego, B Álvarez-Bernad, B Pera, C Wullschleger, O...

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#paperhighlights Nov2022 #4

#paperhighlights Nov2022 #4

Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1 R Pluta, E Aragón, N A Prescott, L Ruiz, R A Mees, B...

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#paperhighlights Nov2022 #3

#paperhighlights Nov2022 #3

Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus A Rivera-Calzada, R Arribas-Bosacoma, A Ruiz-Ramos, P...

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#paperhighlights Nov2022 #2

#paperhighlights Nov2022 #2

Active boundary layers in confined active nematics J Hardoüin, C Doré, J Laurent, T Lopez-Leon, J Ignés-Mullol & F Sagués Nature Communications...

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#paperhighlights Nov2022 #1

#paperhighlights Nov2022 #1

A glutamine-based single α-helix scaffold to target globular proteins A Escobedo, J Piccirillo, J  Aranda, T  Diercks, B  Mateos, C Garcia-Cabau, M...

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#paperhighlights Oct2022 #3

#paperhighlights Oct2022 #3

Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid–liquid phase...

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#paperhighligths  Oct2022 #2

#paperhighligths Oct2022 #2

TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine D Alarcón-Alarcón, D Cabañero,...

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#paperhighlights Oct2022 #1

#paperhighlights Oct2022 #1

CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase J P López-Alonso, M Lázaro, D Gil-Cartón, P H Choi, A Dodu, L Tong...

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#paperhighlights Aug2022 #4

#paperhighlights Aug2022 #4

Mechanical strain stimulates COPII-dependent secretory trafficking via Rac1 Phuyal S, Djaerff E, Le Roux AL, Baker MJ, Fankhauser D, Mahdizadeh...

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#paperhighlights Aug2022 #3

#paperhighlights Aug2022 #3

Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau Gracia P, Polanco D, Tarancón-Díez...

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#paperhighlights Aug 2022 #2

#paperhighlights Aug 2022 #2

Stochastic particle unbinding modulates growth dynamics and size of transcription factor condensates in living cells Muñoz-Gil G, Romero-Aristizabal...

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#paperhighlights Aug2022 #1

#paperhighlights Aug2022 #1

A quantitative biophysical principle to explain the 3D cellular connectivity in curved epithelia Gómez-Gálvez P, Vicente-Munuera P, Anbari S, Tagua...

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#paperhighlights July2022 #1

#paperhighlights July2022 #1

The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation Ginex T,...

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#paperhighlights June2022 #3

#paperhighlights June2022 #3

Mechanical force application to the nucleus regulates nucleocytoplasmic transport I Andreu, I Granero-Moya, N R Chahare, K Clein, M Molina-Jordán, A...

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#paperhighlights June2022 #2

#paperhighlights June2022 #2

Basal oxidation of conserved cysteines modulates cardiac titin stiffness and dynamics E Herrero-Galán, I Martínez-Martín, C Sánchez-González, N...

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#paperhighlights June2022 #1

#paperhighlights June2022 #1

All-atom molecular dynamics simulations of Synaptotagmin-SNARE-complexin complexes bridging a vesicle and a flat lipid bilayer J Rizo,L Sari, Y Qi,...

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#paperhighlights May2022 #1

#paperhighlights May2022 #1

Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2 J Aranda, M Wieczór, M Terrazas, I Brun-Heath, M Orozco Chem. Catal 2(5):...

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#paperhighlights Apr2022 #2

#paperhighlights Apr2022 #2

Human HELB is a processive motor protein that catalyzes RPA clearance from single-stranded DNA S Hormeno, OJ Wilkinson, C Aicart-Ramos, S Kuppa, E...

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#paperhighlights Apr2022 #1

#paperhighlights Apr2022 #1

Radiationless mechanism of UV deactivation by cuticle phenolics in plants. A González Moreno, A de Cózar, P Prieto, E Domínguez, A Heredia Nat...

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#paperhighlights Mar2022 #2

#paperhighlights Mar2022 #2

Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase M García-Alija, JJ Du, I Ordóñez, A Diz-Vallenilla, A...

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#paperhighlights Mar2022 #1

#paperhighlights Mar2022 #1

A Genetically Engineered, Chain Mail-Like Nanostructured Protein Material with Increased Fatigue Resistance and Enhanced Self-Healing S...

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#paperhighlights Feb2022 #2

#paperhighlights Feb2022 #2

Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor B Herguedas, BK Kohegyi, JN Dohrke, JF Watson, D Zhang, H Ho, SA Shaikh, R...

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#paperhighlights Feb2022 #1

#paperhighlights Feb2022 #1

The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation K Cosentino, V Hertlein, A Jenner,...

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#paperhighlights Jan2022 #4

#paperhighlights Jan2022 #4

Synthetic multistability in mammalian cells R Zhu, JM Del Rio-Salgado, J Garcia-Ojalvo, MB Elowitz Science 375(6578):eabg9765 (2022).   doi:...

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#paperhighlights Jan2022 #3

#paperhighlights Jan2022 #3

Stem–loop formation drives RNA folding in mechanical unzipping experiments P. Rissone, C. V. Bizarro, F. Ritort PNAS 119 (3) e2025575119 (2022) doi:...

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#paperhighlights Jan2022 #2

#paperhighlights Jan2022 #2

CryoEM of RUVBL1–RUVBL2–ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8 M. Serna, A. González-Corpas, S. Cabezudo, A....

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#paperhighlights Jan2022 #1

#paperhighlights Jan2022 #1

Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation M. T. Bueno-Carrasco, J. Cuéllar, M....

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#paperhighlights Dec2021 #1

#paperhighlights Dec2021 #1

Inhibition Mechanism of SARS-CoV-2 Main Protease with Ketone-Based Inhibitors Unveiled by Multiscale Simulations: Insights for Improved Designs...

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#paperhighlights Nov2021 #2

#paperhighlights Nov2021 #2

Cage–···Cage– Interaction: Boron Cluster-Based Noncovalent Bond and Its Applications in Solid-State Materials Tu D, Li J, Sun F,Yan H,Poater J, Solà...

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#paperhighlights Nov2021 #1

#paperhighlights Nov2021 #1

Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C1C2B region M Camacho, B Quade, T Trimbuch, J Xu, L...

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#paperhighlights Oct2021 #2

#paperhighlights Oct2021 #2

Unexpected Disparity in Photoinduced Reactions of C60 and C70 in Water with the Generation of O2•– or 1O2 Liosi K, Stasyuk A J, Masero F, Voityuk A...

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#paperhighlights Oct2021 #1

#paperhighlights Oct2021 #1

Objective comparison of methods to decode anomalous diffusion G Muñoz-Gil, Giov Volpe, M A Garcia-March, E Aghion, A Argun, C Beom Hong, T Bland, S...

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#paperhighlights Aug2021 #3

#paperhighlights Aug2021 #3

Assisted assembly of bacteriophage T7 core components for genome translocation across the bacterial envelope Pérez-Ruiz M, Pulido-Cid M,...

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#paperhighlights Aug2021 #2

#paperhighlights Aug2021 #2

NMDA receptor-BK channel coupling regulates synaptic plasticity in the barrel cortex Gómez R, Maglio LE, Gonzalez-Hernandez AJ, Rivero-Pérez B,...

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#paperhighlights Aug2021 #1

#paperhighlights Aug2021 #1

The structure of i-motif/duplex junctions at neutral pH Serrano-Chacón I, Mir B, Escaja N, González C J Am Chem Soc 143(33):12919-12923 (2021) doi:...

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#paperhighlights Jul2021 #1

#paperhighlights Jul2021 #1

The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening Andreu I, Falcones B, Hurst S, Chahare N,...

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#paperhighlights Jun2021 #3

#paperhighlights Jun2021 #3

Nanomechanical Phenotypes in Cardiac Myosin-Binding Protein C Mutants That Cause Hypertrophic Cardiomyopathy Suay-Corredera C, Pricolo MR,...

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#paperhighlights Jun2021 #2

#paperhighlights Jun2021 #2

Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers Rujas E, Kucharska I, Tan YZ, Benlekbir S, Cui H, Zhao T, Wasney GA,...

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#paperhighlights Jun2021 #1

#paperhighlights Jun2021 #1

α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity Santos J, Gracia P, Navarro S, Peña-Díaz S, Pujols J,...

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#paperhighlights May2021 #1

#paperhighlights May2021 #1

Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial...

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#paperhighlights May2021 #2

#paperhighlights May2021 #2

The Role of Non-Covalent Interactions on Cluster Formation: Pentamer, Hexamers and Heptamer of Difluoromethane Calabrese C, Temelso B, Usabiaga I,...

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#paperhighlights Apr2021 #1

#paperhighlights Apr2021 #1

Structure and evolutionary trace-assisted screening of a residue swapping the substrate ambiguity and chiral specificity in an esterase Cea-Rama I,...

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#paperhighlights Mar2021 #2

#paperhighlights Mar2021 #2

Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity Modi T, Risso VA,...

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#paperhighlights Mar2021 #1

#paperhighlights Mar2021 #1

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells Cascella R, Chen SW, Bigi A, Camino JD, Xu CK, Dobson...

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#paperhighlights Feb2021 #1

#paperhighlights Feb2021 #1

Adrenergic Modulation With Photochromic Ligands Prischich D, Gomila AMJ, Milla-Navarro S, Sangüesa G, Diez-Alarcia R, Preda B, Matera C, Batlle M,...

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#paperhighlights Jan2021 #2

#paperhighlights Jan2021 #2

Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase Gamiz-Arco G, Gutierrez-Rus LI, Risso VA, Ibarra-Molero B, Hoshino...

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#paperhighlights Jan2021 #1

#paperhighlights Jan2021 #1

FSC-Q: a CryoEM map-to-atomic model quality validation based on the local Fourier shell correlation Ramírez-Aportela E, Maluenda D, Fonseca YC,...

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#paperhighlights Dec2020 #1

#paperhighlights Dec2020 #1

Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase Zimmermann F, Serna M, Ezquerra A, Fernandez-Leiro R, Llorca O,...

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#paperhighlights Nov2020 #2

#paperhighlights Nov2020 #2

Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM López-Perrote A, Hug N,...

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#paperhighlights Nov2020 #1

#paperhighlights Nov2020 #1

Cell Photocontrol of Endogenous Glycine Receptors In Vivo Gomila AMJ, Rustler K, Maleeva G, Nin-Hill A, Wutz D, Bautista-Barrufet A, Rovira X, Bosch...

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#paperhighlights Oct2020 #2

#paperhighlights Oct2020 #2

Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies Rujas E, Cui H, Sicard T,...

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#paperhighlights Oct2020 #1

#paperhighlights Oct2020 #1

The extent of protein hydration dictates the preference for heterogeneous or homogeneous nucleation generating either parallel or antiparallel...

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#paperhighlights Sept2020 #2

#paperhighlights Sept2020 #2

Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila Trastoy B, Naegeli A, Anso I,...

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