Paper highlights

"Exploring the druggability of the UEV domain of human TSG101 in search for broad-spectrumantivirals. " Montero F, Parra-López M, Rodríguez-Martínez...

Photoswitchable Diazocine Derivative for Adenosine A3 Receptor Activation in Psoriasis   López-Cano M, Scortichini M, Tosh DK, Salmaso V, Ko T,...

"A lever hypothesis for Synaptotagmin-1 action in neurotransmitter release." JJaczynska K, Esser V, Xu J, Sari L, Lin MM, Rosenmund C, Rizo J.  Proc...

Mis-splicing of a neuronal microexon promotes CPEB4 aggregation in ASD. Garcia-Cabau C, Bartomeu A, Tesei G, Cheung KC, Pose-Utrilla J, Picó...

Stacking correlation length in single-stranded DNA. Viader-Godoy X, Manosas M, Ritort F. Nucleic Acids Res. 2024 Nov 27;52(21):13243-13254....

Tensing Flipper: Photosensitized Manipulation of Membrane Tension, Lipid Phase Separation, and Raft Protein Sorting in Biological Membranes Torra J,...

Membrane fission via transmembrane contact Spencer RKW, Santos-Pérez I, Rodríguez-Renovales I, Martinez Galvez JM, Shnyrova AV & Müller M Nat...

Single-Molecule Analysis of Genome Uncoating from Individual Human Rhinovirus Particles, and Modulation by Antiviral Drugs Valbuena A, Strobl K,...

Transition of human γ-tubulin ring complex into a closed conformation during microtubule nucleation Brito C, Serna M, Guerra P, Llorca O &...

Variance sum rule for entropy production Di Terlizzi I, Gironella M, Herraez-Aguilar D, Betz T, Monroy F, Baiesi M & Ritort F Science 383(6686):...

Charged Biological Membranes Repel Large Neutral Molecules by Surface Dielectrophoresis and Counterion Pressure M Aguilella-Arzo, D P Hoogerheide, M...

Molecular Dynamic Simulations of Aqueous Micellar Organometallic Catalysis: Methane Functionalization as a Case Study A Matamoros-Recio, E...

Flexible structural arrangement and DNA-binding properties of protein p6 from Bacillus subtillis phage φ29 M Alcorlo, J R Luque-Ortega, F Gago, A...

Three-Photon Infrared Stimulation of Endogenous Neuroreceptors in Vivo R Sortino, M Cunquero, G Castro-Olvera, R Gelabert, M Moreno, F Riefolo, C...

Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α J Pous, B Baginski, P Martin-Malpartida, L...

Rational optimization of a transcription factor activation domain inhibitor S Basu, P Martínez-Cristóbal, M Frigolé-Vivas, M Pesarrodona, M Lewis, E...

Molecular Sensing and Manipulation of Protein Oligomerization in Membrane Nanotubes with Bolaamphiphilic Foldamers K Aftahy, P Arrasate, P V...

Three-Dimensional Remodeling of SARS-CoV2-Infected Cells Revealed by Cryogenic Soft X-ray Tomography V Castro, A Joaquina Pérez-Berna, G Calvo, E...

Structural and functional insights into the delivery of a bacterial Rhs pore-forming toxin to the membrane A González-Magaña, I Tascón, J...

The laminin–keratin link shields the nucleus from mechanical deformation and signalling Z Kechagia, P Sáez, M Gómez-González, B Canales, S...

A MEC-2/stomatin condensate liquid-to-solid phase transition controls neuronal mechanotransduction during touch sensing N Sanfeliu-Cerdán, F...

Single─Not Double─3D-Aromaticity in an Oxidized Closo Icosahedral Dodecaiodo-Dodecaborate Cluster J Poater, S Escayola, A Poater, F Teixidor, H...

The Protein Matrix of Plastocyanin Supports Long-Distance Charge Transport with Photosystem I and the Copper Ion Regulates Its Spatial Span and...

Sub-micro- and nano-sized polyethylene terephthalate deconstruction with engineered protein nanopores Robles-Martín A, Amigot-Sánchez R,...

The self-association equilibrium of DNAJA2 regulates its interaction with unfolded substrate proteins and with Hsc70 L Velasco-Carneros, J Cuéllar,...

A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale X Quiroga, N Walani. A Disanza, A Chavero, A Mittens, F...

Mitochondrial integrated stress response controls lung epithelial cell fate S H Han, M Lee, Y Shin, R Giovanni, R P Chakrabarty, M M Herrerias, L A...

Amyloid Fibrils Formed by Short Prion-Inspired Peptides Are Metalloenzymes S Navarro, M Díaz-Caballero, F Peccati, L Roldán-Martín, M Sodupe & S...

A multi-enzyme machine polymerizes the Haemophilus influenzae type b capsule J O Cifuente, J Schulze, A Bethe, V Di Domenico, C Litschko, I Budde, L...

Cytochrome c lysine acetylation regulates cellular respiration and cell death in ischemic skeletal muscle P T Morse, G Pérez-Mejías, J Wan, A A...

Structural analysis of the Candida albicans mitochondrial DNA maintenance factor Gcf1p reveals a dynamic DNA-bridging mechanism A Tarrés-Solé, F...

Characterization of p38α autophosphorylation inhibitors that target the non-canonical activation pathway L González, L Díaz, J Pous, B Baginski, A...

Architecture of the ESCPE-1 membrane coat C Lopez-Robles, S Scaramuzza, E N Astorga-Simon, M Ishida, C D Williamson, S Baños-Mateos, D Gil-Carton, M...

Expanded Conformations of Monomeric Tau Initiate Its Amyloidogenesis MdC Fernández-Ramírez, K K-S Ng, M Menéndez, D V Laurents, R Hervás, & M...

Hybrid Plasmonic Nanostructures for Enhanced Single-Molecule Detection Sensitivity E K Herkert, D R Bermeo Alvaro, M Recchia, W Langbein, P Borri,...

LC3/GABARAP binding to fluid membranes is potentiated by ceramide YR Varela & A Alonso  Autophagy, 19(4): 1371-1373, (2023) doi:...

Correlated motions in DNA: beyond base-pair step models of DNA flexibility  K López-Güell, F Battistini, & M Orozco Nucleic Acids Research,...

Transgenic NADH dehydrogenase restores oxygen regulation of breathing in mitochondrial complex I-deficient mice B Jiménez-Gómez, P Ortega-Sáenz, L...

Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration PQ Nguyen, S Huecas, A Asif-Laidin, A...

Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases B Trastoy, JJ Du, JO Cifuente, L...

Mechanism of strand displacement DNA synthesis by the coordinated activities of human mitochondrial DNA polymerase and SSB I Plaza-G A, K M...

pH-Dependent Capping Interactions Induce Large-Scale Structural Transitions in i-Motifs I Serrano-Chacón, B Mir, L Cupellini, F Colizzi, M Orozco, N...

Facile Construction of New Hybrid Conjugation via Boron Cage Extension F Sun, S Tan, H-J Cao, C Lu, D Tu, J Poater, M Solà & H Yan J. Am. Chem....

Estimating conformational landscapes from Cryo-EM particles by 3D Zernike polynomials D Herreros, R R Lederman, J M Krieger, A Jiménez-Moreno, M...

Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3 J Garcia-Pardo, A Bartolomé-Nafría, A...

Metamorphism in TDP-43 prion-like domain determines chaperone recognition J Carrasco, R Antón, A Valbuena, D Pantoja-Uceda, M Mukhi, R Hervás, D V...

Molecular architecture and oligomerization of Candida glabrata Cdc13 underpin its telomeric DNA-binding and unfolding activity J Coloma, N...

Geometric deep learning reveals the spatiotemporal features of microscopic motion J Pineda, B Midtvedt, H Bachimanchi, S Noé, D Midtvedt, G Volpe...

LC3 subfamily in cardiolipin-mediated mitophagy: a comparison of the LC3A, LC3B and LC3C homologs M N Iriondo, A Etxaniz, Y R Varela, U Ballesteros,...

APLF and long non-coding RNA NIHCOLE promote stable DNA synapsis in non-homologous end joining S De Bragança, C Aicart-Ramos, R Arribas-Bosacoma, A...

Proton Transfers to DNA in Native Electrospray Ionization Mass Spectrometry: A Quantum Mechanics/Molecular Mechanics Study M Paulikat, J Aranda, E...

Chemical modulation of microtubule structure through the laulimalide/peloruside site J Estévez-Gallego, B Álvarez-Bernad, B Pera, C Wullschleger, O...

Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1 R Pluta, E Aragón, N A Prescott, L Ruiz, R A Mees, B...

Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus A Rivera-Calzada, R Arribas-Bosacoma, A Ruiz-Ramos, P...

Active boundary layers in confined active nematics J Hardoüin, C Doré, J Laurent, T Lopez-Leon, J Ignés-Mullol & F Sagués Nature Communications...

A glutamine-based single α-helix scaffold to target globular proteins A Escobedo, J Piccirillo, J  Aranda, T  Diercks, B  Mateos, C Garcia-Cabau, M...

Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid–liquid phase...

TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine D Alarcón-Alarcón, D Cabañero,...

CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase J P López-Alonso, M Lázaro, D Gil-Cartón, P H Choi, A Dodu, L Tong...

Mechanical strain stimulates COPII-dependent secretory trafficking via Rac1 Phuyal S, Djaerff E, Le Roux AL, Baker MJ, Fankhauser D, Mahdizadeh...

Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau Gracia P, Polanco D, Tarancón-Díez...

Stochastic particle unbinding modulates growth dynamics and size of transcription factor condensates in living cells Muñoz-Gil G, Romero-Aristizabal...

A quantitative biophysical principle to explain the 3D cellular connectivity in curved epithelia Gómez-Gálvez P, Vicente-Munuera P, Anbari S, Tagua...

The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation Ginex T,...

Mechanical force application to the nucleus regulates nucleocytoplasmic transport I Andreu, I Granero-Moya, N R Chahare, K Clein, M Molina-Jordán, A...

Basal oxidation of conserved cysteines modulates cardiac titin stiffness and dynamics E Herrero-Galán, I Martínez-Martín, C Sánchez-González, N...

All-atom molecular dynamics simulations of Synaptotagmin-SNARE-complexin complexes bridging a vesicle and a flat lipid bilayer J Rizo,L Sari, Y Qi,...

Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2 J Aranda, M Wieczór, M Terrazas, I Brun-Heath, M Orozco Chem. Catal 2(5):...

Human HELB is a processive motor protein that catalyzes RPA clearance from single-stranded DNA S Hormeno, OJ Wilkinson, C Aicart-Ramos, S Kuppa, E...

Radiationless mechanism of UV deactivation by cuticle phenolics in plants. A González Moreno, A de Cózar, P Prieto, E Domínguez, A Heredia Nat...

Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase M García-Alija, JJ Du, I Ordóñez, A Diz-Vallenilla, A...

A Genetically Engineered, Chain Mail-Like Nanostructured Protein Material with Increased Fatigue Resistance and Enhanced Self-Healing S...

Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor B Herguedas, BK Kohegyi, JN Dohrke, JF Watson, D Zhang, H Ho, SA Shaikh, R...

The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation K Cosentino, V Hertlein, A Jenner,...

Synthetic multistability in mammalian cells R Zhu, JM Del Rio-Salgado, J Garcia-Ojalvo, MB Elowitz Science 375(6578):eabg9765 (2022).   doi:...

Stem–loop formation drives RNA folding in mechanical unzipping experiments P. Rissone, C. V. Bizarro, F. Ritort PNAS 119 (3) e2025575119 (2022) doi:...