Paper highlights
#paperhighlights Mar2023 #3
Transgenic NADH dehydrogenase restores oxygen regulation of breathing in mitochondrial complex I-deficient mice B Jiménez-Gómez, P Ortega-Sáenz, L...
#paperhighlights Mar2023 #2
Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration PQ Nguyen, S Huecas, A Asif-Laidin, A...
#paperhighlights Mar2023 #1
Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases B Trastoy, JJ Du, JO Cifuente, L...
#paperhighlights Feb2023 #4
Mechanism of strand displacement DNA synthesis by the coordinated activities of human mitochondrial DNA polymerase and SSB I Plaza-G A, K M...
#paperhighlights Feb2023 #3
pH-Dependent Capping Interactions Induce Large-Scale Structural Transitions in i-Motifs I Serrano-Chacón, B Mir, L Cupellini, F Colizzi, M Orozco, N...
#paperhighlights Feb2023 #2
Facile Construction of New Hybrid Conjugation via Boron Cage Extension F Sun, S Tan, H-J Cao, C Lu, D Tu, J Poater, M Solà & H Yan J. Am. Chem....
#paperhighlights Feb2023 #1
Estimating conformational landscapes from Cryo-EM particles by 3D Zernike polynomials D Herreros, R R Lederman, J M Krieger, A Jiménez-Moreno, M...
#paperhighlights Jan2023 #4
Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3 J Garcia-Pardo, A Bartolomé-Nafría, A...
#paperhighlights Jan2023 #3
Metamorphism in TDP-43 prion-like domain determines chaperone recognition J Carrasco, R Antón, A Valbuena, D Pantoja-Uceda, M Mukhi, R Hervás, D V...
#paperhighlights Jan2023 #2
Molecular architecture and oligomerization of Candida glabrata Cdc13 underpin its telomeric DNA-binding and unfolding activity J Coloma, N...
#paperhighlights Jan2023 #1
Geometric deep learning reveals the spatiotemporal features of microscopic motion J Pineda, B Midtvedt, H Bachimanchi, S Noé, D Midtvedt, G Volpe...
#paperhighlights Dec2022 #4
LC3 subfamily in cardiolipin-mediated mitophagy: a comparison of the LC3A, LC3B and LC3C homologs M N Iriondo, A Etxaniz, Y R Varela, U Ballesteros,...
#paperhighlights Dec2022 #3
APLF and long non-coding RNA NIHCOLE promote stable DNA synapsis in non-homologous end joining S De Bragança, C Aicart-Ramos, R Arribas-Bosacoma, A...
#paperhighlights Dec2022 #2
Proton Transfers to DNA in Native Electrospray Ionization Mass Spectrometry: A Quantum Mechanics/Molecular Mechanics Study M Paulikat, J Aranda, E...
#paperhighlights Dec2022 #1
Chemical modulation of microtubule structure through the laulimalide/peloruside site J Estévez-Gallego, B Álvarez-Bernad, B Pera, C Wullschleger, O...
#paperhighlights Nov2022 #4
Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1 R Pluta, E Aragón, N A Prescott, L Ruiz, R A Mees, B...
#paperhighlights Nov2022 #3
Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus A Rivera-Calzada, R Arribas-Bosacoma, A Ruiz-Ramos, P...
#paperhighlights Nov2022 #2
Active boundary layers in confined active nematics J Hardoüin, C Doré, J Laurent, T Lopez-Leon, J Ignés-Mullol & F Sagués Nature Communications...
#paperhighlights Nov2022 #1
A glutamine-based single α-helix scaffold to target globular proteins A Escobedo, J Piccirillo, J Aranda, T Diercks, B Mateos, C Garcia-Cabau, M...
#paperhighlights Oct2022 #3
Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid–liquid phase...
#paperhighligths Oct2022 #2
TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine D Alarcón-Alarcón, D Cabañero,...
#paperhighlights Oct2022 #1
CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase J P López-Alonso, M Lázaro, D Gil-Cartón, P H Choi, A Dodu, L Tong...
#paperhighlights Aug2022 #4
Mechanical strain stimulates COPII-dependent secretory trafficking via Rac1 Phuyal S, Djaerff E, Le Roux AL, Baker MJ, Fankhauser D, Mahdizadeh...
#paperhighlights Aug2022 #3
Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau Gracia P, Polanco D, Tarancón-Díez...
#paperhighlights Aug 2022 #2
Stochastic particle unbinding modulates growth dynamics and size of transcription factor condensates in living cells Muñoz-Gil G, Romero-Aristizabal...
#paperhighlights Aug2022 #1
A quantitative biophysical principle to explain the 3D cellular connectivity in curved epithelia Gómez-Gálvez P, Vicente-Munuera P, Anbari S, Tagua...
#paperhighlights July2022 #1
The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation Ginex T,...
#paperhighlights June2022 #3
Mechanical force application to the nucleus regulates nucleocytoplasmic transport I Andreu, I Granero-Moya, N R Chahare, K Clein, M Molina-Jordán, A...
#paperhighlights June2022 #2
Basal oxidation of conserved cysteines modulates cardiac titin stiffness and dynamics E Herrero-Galán, I Martínez-Martín, C Sánchez-González, N...
#paperhighlights June2022 #1
All-atom molecular dynamics simulations of Synaptotagmin-SNARE-complexin complexes bridging a vesicle and a flat lipid bilayer J Rizo,L Sari, Y Qi,...
#paperhighlights May2022 #1
Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2 J Aranda, M Wieczór, M Terrazas, I Brun-Heath, M Orozco Chem. Catal 2(5):...
#paperhighlights Apr2022 #2
Human HELB is a processive motor protein that catalyzes RPA clearance from single-stranded DNA S Hormeno, OJ Wilkinson, C Aicart-Ramos, S Kuppa, E...
#paperhighlights Apr2022 #1
Radiationless mechanism of UV deactivation by cuticle phenolics in plants. A González Moreno, A de Cózar, P Prieto, E Domínguez, A Heredia Nat...
#paperhighlights Mar2022 #2
Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase M García-Alija, JJ Du, I Ordóñez, A Diz-Vallenilla, A...
#paperhighlights Mar2022 #1
A Genetically Engineered, Chain Mail-Like Nanostructured Protein Material with Increased Fatigue Resistance and Enhanced Self-Healing S...
#paperhighlights Feb2022 #2
Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor B Herguedas, BK Kohegyi, JN Dohrke, JF Watson, D Zhang, H Ho, SA Shaikh, R...
#paperhighlights Feb2022 #1
The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation K Cosentino, V Hertlein, A Jenner,...
#paperhighlights Jan2022 #4
Synthetic multistability in mammalian cells R Zhu, JM Del Rio-Salgado, J Garcia-Ojalvo, MB Elowitz Science 375(6578):eabg9765 (2022). doi:...
#paperhighlights Jan2022 #3
Stem–loop formation drives RNA folding in mechanical unzipping experiments P. Rissone, C. V. Bizarro, F. Ritort PNAS 119 (3) e2025575119 (2022) doi:...
#paperhighlights Jan2022 #2
CryoEM of RUVBL1–RUVBL2–ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8 M. Serna, A. González-Corpas, S. Cabezudo, A....
#paperhighlights Jan2022 #1
Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation M. T. Bueno-Carrasco, J. Cuéllar, M....
#paperhighlights Dec2021 #1
Inhibition Mechanism of SARS-CoV-2 Main Protease with Ketone-Based Inhibitors Unveiled by Multiscale Simulations: Insights for Improved Designs...
#paperhighlights Nov2021 #2
Cage–···Cage– Interaction: Boron Cluster-Based Noncovalent Bond and Its Applications in Solid-State Materials Tu D, Li J, Sun F,Yan H,Poater J, Solà...
#paperhighlights Nov2021 #1
Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C1C2B region M Camacho, B Quade, T Trimbuch, J Xu, L...
#paperhighlights Oct2021 #2
Unexpected Disparity in Photoinduced Reactions of C60 and C70 in Water with the Generation of O2•– or 1O2 Liosi K, Stasyuk A J, Masero F, Voityuk A...
#paperhighlights Oct2021 #1
Objective comparison of methods to decode anomalous diffusion G Muñoz-Gil, Giov Volpe, M A Garcia-March, E Aghion, A Argun, C Beom Hong, T Bland, S...
#paperhighlights Aug2021 #3
Assisted assembly of bacteriophage T7 core components for genome translocation across the bacterial envelope Pérez-Ruiz M, Pulido-Cid M,...
#paperhighlights Aug2021 #2
NMDA receptor-BK channel coupling regulates synaptic plasticity in the barrel cortex Gómez R, Maglio LE, Gonzalez-Hernandez AJ, Rivero-Pérez B,...
#paperhighlights Aug2021 #1
The structure of i-motif/duplex junctions at neutral pH Serrano-Chacón I, Mir B, Escaja N, González C J Am Chem Soc 143(33):12919-12923 (2021) doi:...
#paperhighlights Jul2021 #1
The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening Andreu I, Falcones B, Hurst S, Chahare N,...
#paperhighlights Jun2021 #3
Nanomechanical Phenotypes in Cardiac Myosin-Binding Protein C Mutants That Cause Hypertrophic Cardiomyopathy Suay-Corredera C, Pricolo MR,...
#paperhighlights Jun2021 #2
Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers Rujas E, Kucharska I, Tan YZ, Benlekbir S, Cui H, Zhao T, Wasney GA,...
#paperhighlights Jun2021 #1
α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity Santos J, Gracia P, Navarro S, Peña-Díaz S, Pujols J,...
#paperhighlights May2021 #1
Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial...
#paperhighlights May2021 #2
The Role of Non-Covalent Interactions on Cluster Formation: Pentamer, Hexamers and Heptamer of Difluoromethane Calabrese C, Temelso B, Usabiaga I,...
#paperhighlights Apr2021 #1
Structure and evolutionary trace-assisted screening of a residue swapping the substrate ambiguity and chiral specificity in an esterase Cea-Rama I,...
#paperhighlights Mar2021 #2
Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity Modi T, Risso VA,...
#paperhighlights Mar2021 #1
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells Cascella R, Chen SW, Bigi A, Camino JD, Xu CK, Dobson...
#paperhighlights Feb2021 #1
Adrenergic Modulation With Photochromic Ligands Prischich D, Gomila AMJ, Milla-Navarro S, Sangüesa G, Diez-Alarcia R, Preda B, Matera C, Batlle M,...
#paperhighlights Jan2021 #2
Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase Gamiz-Arco G, Gutierrez-Rus LI, Risso VA, Ibarra-Molero B, Hoshino...
#paperhighlights Jan2021 #1
FSC-Q: a CryoEM map-to-atomic model quality validation based on the local Fourier shell correlation Ramírez-Aportela E, Maluenda D, Fonseca YC,...
#paperhighlights Dec2020 #1
Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase Zimmermann F, Serna M, Ezquerra A, Fernandez-Leiro R, Llorca O,...
#paperhighlights Nov2020 #2
Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM López-Perrote A, Hug N,...
#paperhighlights Nov2020 #1
Cell Photocontrol of Endogenous Glycine Receptors In Vivo Gomila AMJ, Rustler K, Maleeva G, Nin-Hill A, Wutz D, Bautista-Barrufet A, Rovira X, Bosch...
#paperhighlights Oct2020 #2
Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies Rujas E, Cui H, Sicard T,...
#paperhighlights Oct2020 #1
The extent of protein hydration dictates the preference for heterogeneous or homogeneous nucleation generating either parallel or antiparallel...
#paperhighlights Sept2020 #2
Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila Trastoy B, Naegeli A, Anso I,...
#paperhighlights Sept2020 #1
The crystal structure of human XPG, the xeroderma pigmentosum group G endonuclease, provides insight into nucleotide excision DNA repair...