Paper highlights

Transgenic NADH dehydrogenase restores oxygen regulation of breathing in mitochondrial complex I-deficient mice B Jiménez-Gómez, P Ortega-Sáenz, L...

Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration PQ Nguyen, S Huecas, A Asif-Laidin, A...

Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases B Trastoy, JJ Du, JO Cifuente, L...

Mechanism of strand displacement DNA synthesis by the coordinated activities of human mitochondrial DNA polymerase and SSB I Plaza-G A, K M...

pH-Dependent Capping Interactions Induce Large-Scale Structural Transitions in i-Motifs I Serrano-Chacón, B Mir, L Cupellini, F Colizzi, M Orozco, N...

Facile Construction of New Hybrid Conjugation via Boron Cage Extension F Sun, S Tan, H-J Cao, C Lu, D Tu, J Poater, M Solà & H Yan J. Am. Chem....

Estimating conformational landscapes from Cryo-EM particles by 3D Zernike polynomials D Herreros, R R Lederman, J M Krieger, A Jiménez-Moreno, M...

Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3 J Garcia-Pardo, A Bartolomé-Nafría, A...

Metamorphism in TDP-43 prion-like domain determines chaperone recognition J Carrasco, R Antón, A Valbuena, D Pantoja-Uceda, M Mukhi, R Hervás, D V...

Molecular architecture and oligomerization of Candida glabrata Cdc13 underpin its telomeric DNA-binding and unfolding activity J Coloma, N...

Geometric deep learning reveals the spatiotemporal features of microscopic motion J Pineda, B Midtvedt, H Bachimanchi, S Noé, D Midtvedt, G Volpe...

LC3 subfamily in cardiolipin-mediated mitophagy: a comparison of the LC3A, LC3B and LC3C homologs M N Iriondo, A Etxaniz, Y R Varela, U Ballesteros,...

APLF and long non-coding RNA NIHCOLE promote stable DNA synapsis in non-homologous end joining S De Bragança, C Aicart-Ramos, R Arribas-Bosacoma, A...

Proton Transfers to DNA in Native Electrospray Ionization Mass Spectrometry: A Quantum Mechanics/Molecular Mechanics Study M Paulikat, J Aranda, E...

Chemical modulation of microtubule structure through the laulimalide/peloruside site J Estévez-Gallego, B Álvarez-Bernad, B Pera, C Wullschleger, O...

Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1 R Pluta, E Aragón, N A Prescott, L Ruiz, R A Mees, B...

Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus A Rivera-Calzada, R Arribas-Bosacoma, A Ruiz-Ramos, P...

Active boundary layers in confined active nematics J Hardoüin, C Doré, J Laurent, T Lopez-Leon, J Ignés-Mullol & F Sagués Nature Communications...

A glutamine-based single α-helix scaffold to target globular proteins A Escobedo, J Piccirillo, J  Aranda, T  Diercks, B  Mateos, C Garcia-Cabau, M...

Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid–liquid phase...

TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine D Alarcón-Alarcón, D Cabañero,...

CryoEM structural exploration of catalytically active enzyme pyruvate carboxylase J P López-Alonso, M Lázaro, D Gil-Cartón, P H Choi, A Dodu, L Tong...

Mechanical strain stimulates COPII-dependent secretory trafficking via Rac1 Phuyal S, Djaerff E, Le Roux AL, Baker MJ, Fankhauser D, Mahdizadeh...

Molecular mechanism for the synchronized electrostatic coacervation and co-aggregation of alpha-synuclein and tau Gracia P, Polanco D, Tarancón-Díez...

Stochastic particle unbinding modulates growth dynamics and size of transcription factor condensates in living cells Muñoz-Gil G, Romero-Aristizabal...

A quantitative biophysical principle to explain the 3D cellular connectivity in curved epithelia Gómez-Gálvez P, Vicente-Munuera P, Anbari S, Tagua...

The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation Ginex T,...

Mechanical force application to the nucleus regulates nucleocytoplasmic transport I Andreu, I Granero-Moya, N R Chahare, K Clein, M Molina-Jordán, A...

Basal oxidation of conserved cysteines modulates cardiac titin stiffness and dynamics E Herrero-Galán, I Martínez-Martín, C Sánchez-González, N...

All-atom molecular dynamics simulations of Synaptotagmin-SNARE-complexin complexes bridging a vesicle and a flat lipid bilayer J Rizo,L Sari, Y Qi,...

Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2 J Aranda, M Wieczór, M Terrazas, I Brun-Heath, M Orozco Chem. Catal 2(5):...

Human HELB is a processive motor protein that catalyzes RPA clearance from single-stranded DNA S Hormeno, OJ Wilkinson, C Aicart-Ramos, S Kuppa, E...

Radiationless mechanism of UV deactivation by cuticle phenolics in plants. A González Moreno, A de Cózar, P Prieto, E Domínguez, A Heredia Nat...

Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase M García-Alija, JJ Du, I Ordóñez, A Diz-Vallenilla, A...

A Genetically Engineered, Chain Mail-Like Nanostructured Protein Material with Increased Fatigue Resistance and Enhanced Self-Healing S...

Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor B Herguedas, BK Kohegyi, JN Dohrke, JF Watson, D Zhang, H Ho, SA Shaikh, R...

The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation K Cosentino, V Hertlein, A Jenner,...

Synthetic multistability in mammalian cells R Zhu, JM Del Rio-Salgado, J Garcia-Ojalvo, MB Elowitz Science 375(6578):eabg9765 (2022).   doi:...

Stem–loop formation drives RNA folding in mechanical unzipping experiments P. Rissone, C. V. Bizarro, F. Ritort PNAS 119 (3) e2025575119 (2022) doi:...

CryoEM of RUVBL1–RUVBL2–ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8 M. Serna, A. González-Corpas, S. Cabezudo, A....

Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation M. T. Bueno-Carrasco, J. Cuéllar, M....

Inhibition Mechanism of SARS-CoV-2 Main Protease with Ketone-Based Inhibitors Unveiled by Multiscale Simulations: Insights for Improved Designs...

Cage–···Cage– Interaction: Boron Cluster-Based Noncovalent Bond and Its Applications in Solid-State Materials Tu D, Li J, Sun F,Yan H,Poater J, Solà...

Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C1C2B region M Camacho, B Quade, T Trimbuch, J Xu, L...

Unexpected Disparity in Photoinduced Reactions of C60 and C70 in Water with the Generation of O2•– or 1O2 Liosi K, Stasyuk A J, Masero F, Voityuk A...

Objective comparison of methods to decode anomalous diffusion G Muñoz-Gil, Giov Volpe, M A Garcia-March, E Aghion, A Argun, C Beom Hong, T Bland, S...

Assisted assembly of bacteriophage T7 core components for genome translocation across the bacterial envelope Pérez-Ruiz M, Pulido-Cid M,...

NMDA receptor-BK channel coupling regulates synaptic plasticity in the barrel cortex Gómez R, Maglio LE, Gonzalez-Hernandez AJ, Rivero-Pérez B,...

The structure of i-motif/duplex junctions at neutral pH Serrano-Chacón I, Mir B, Escaja N, González C J Am Chem Soc 143(33):12919-12923 (2021) doi:...

The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening Andreu I, Falcones B, Hurst S, Chahare N,...

Nanomechanical Phenotypes in Cardiac Myosin-Binding Protein C Mutants That Cause Hypertrophic Cardiomyopathy Suay-Corredera C, Pricolo MR,...

Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers Rujas E, Kucharska I, Tan YZ, Benlekbir S, Cui H, Zhao T, Wasney GA,...

α-Helical peptidic scaffolds to target α-synuclein toxic species with nanomolar affinity Santos J, Gracia P, Navarro S, Peña-Díaz S, Pujols J,...

Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial...

The Role of Non-Covalent Interactions on Cluster Formation: Pentamer, Hexamers and Heptamer of Difluoromethane Calabrese C, Temelso B, Usabiaga I,...

Structure and evolutionary trace-assisted screening of a residue swapping the substrate ambiguity and chiral specificity in an esterase Cea-Rama I,...

Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity Modi T, Risso VA,...

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells Cascella R, Chen SW, Bigi A, Camino JD, Xu CK, Dobson...

Adrenergic Modulation With Photochromic Ligands Prischich D, Gomila AMJ, Milla-Navarro S, Sangüesa G, Diez-Alarcia R, Preda B, Matera C, Batlle M,...

Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase Gamiz-Arco G, Gutierrez-Rus LI, Risso VA, Ibarra-Molero B, Hoshino...

FSC-Q: a CryoEM map-to-atomic model quality validation based on the local Fourier shell correlation Ramírez-Aportela E, Maluenda D, Fonseca YC,...

Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase Zimmermann F, Serna M, Ezquerra A, Fernandez-Leiro R, Llorca O,...

Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM López-Perrote A, Hug N,...

Cell Photocontrol of Endogenous Glycine Receptors In Vivo Gomila AMJ, Rustler K, Maleeva G, Nin-Hill A, Wutz D, Bautista-Barrufet A, Rovira X, Bosch...

Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies Rujas E, Cui H, Sicard T,...

The extent of protein hydration dictates the preference for heterogeneous or homogeneous nucleation generating either parallel or antiparallel...

Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila Trastoy B, Naegeli A, Anso I,...

The crystal structure of human XPG, the xeroderma pigmentosum group G endonuclease, provides insight into nucleotide excision DNA repair...