![](https://sbe.es/wp-content/uploads/2021/04/Captura-de-pantalla-2021-04-26-a-las-0.14.36.png)
Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity
Modi T, Risso VA, Martinez-Rodriguez S, Gavira JA, Mebrat MD, Van Horn WD, Sanchez-Ruiz JM, Banu Ozkan S
doi: 10.1038/s41467-021-22089-0