#paperhighlights April2024 #1

Architecture of DNAJA2 oligomers. Representative field of a CryoEM image of DNAJA2wt, a cochaperone of Hsp70, with a scale bar corresponding to 100 nm (left panel). The right panel displays side and top views of the atomic model of DNAJA2 fitted into the 3D reconstruction of the protein oligomer. The protein dimers align to form longitudinal filaments that interact laterally, resulting in the helical configuration. Each filament is depicted in distinct color.

“A Targetable N-Terminal Motif Orchestrates α-Synuclein Oligomer-to-Fibril Conversion. 

Santos J, Cuellar J, Pallarès I, Byrd EJ, Lends A, Moro F, Abdul-Shukkoor MB,

Pujols J, Velasco-Carneros L, Sobott F, Otzen DE, Calabrese AN, Muga A, Pedersen

JS, Loquet A, Valpuesta JM, Radford SE, Ventura S.

J Am Chem Soc. 2024;146(18):12702-12711. 

doi: 10.1021/jacs.4c02262. 

https://pubs.acs.org/doi/10.1021/jacs.4c02262

“X” @pfdl