«Sequence-dependent scale for translocon-mediated insertion of interfacial
helices in membranes.»
Grau B, Kormos R, Bañó-Polo M, Chen K, García-Murria MJ, Hajredini F, Sánchez
Del Pino MM, Jo H, Martínez-Gil L, von Heijne G, DeGrado WF, Mingarro I.
Sci Adv. 2025 Feb 21;11(8):eads6804. doi: 10.1126/sciadv.ads6804
In this paper, we devised a system that can differentiate between water-soluble, surface-bound, and transmembrane (TM) states based on its glycosylation pattern. Using this system, we determined the sequence-dependent propensities for transfer from the translocon to a TM, interfacial, or extramembrane space and compared these propensities with the corresponding probability distributions determined from the sequences and structures of experimentally determined proteins.
