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Model showing how the synaptotagmin-1 C2B domain (orange) acts as a lever when it reorients on the membrane upon binding to calcium (blue circles) and pulls the SNARE complex (yellow, red and green), facilitating extension of the synaptobrevin and syntaxin-1 helices such that the transmembrane regions are drawn to the polar interface between the membranes and catalyze membrane fusion in microseconds.