# Highlights Paper 1 May 2025 «Enzyme Enhancement Through Computational Stability Design Targeting NMR-DeterminedCatalytic Hotspots. « Gutierrez-Rus LI, Vos E, Pantoja-Uceda D, Hoffka G, Gutierrez-Cardenas J,Ortega-Muñoz M, Risso VA, Jimenez MA, Kamerlin SCL, Sanchez-Ruiz JM. J Am Chem Soc. 2025 May 7;147(18):14978-14996. doi:10.1021/jacs.4c09428.